GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs17772222 | 1 | rs60310240 | chr14:88822709 | SPATA7 | chr14:88852012-88904802:+ | -0.18 | -3.65 | 0.000291 | Coronary artery calcification |
| THCA | cis | rs55883249 | 1 | rs60319753 | chr2:9767944 | IAH1 | chr2:9614670-9636671:+ | 0.16 | 3.57 | 0.000389 | 3-hydroxy-1-methylpropylmercapturic acid levels in smokers |
| THCA | cis | rs34602589 | 1 | rs6032006 | chr20:43755053 | STK4 | chr20:43595120-43708591:+ | -0.17 | -4.03 | 6.46E-5 | Parental longevity (mother's age at death) |
| THCA | cis | rs1499614 | 1 | rs60326618 | chr7:66166358 | CCT6P1 | chr7:65216092-65228661:+ | 0.43 | 6.6 | 1.1E-10 | Gout |
| THCA | cis | rs1499614 | 1 | rs60326618 | chr7:66166358 | CRCP | chr7:65579805-65619551:+ | -0.29 | -4.34 | 1.77E-5 | Gout |
| THCA | cis | rs1499614 | 1 | rs60326618 | chr7:66166358 | GUSB | chr7:65425675-65447246:- | 0.28 | 3.45 | 0.000613 | Gout |
| THCA | cis | rs1499614 | 1 | rs60326618 | chr7:66166358 | RABGEF1 | chr7:66093890-66276446:+ | 0.63 | 7.69 | 8.35E-14 | Gout |
| THCA | cis | rs2129782 | 1 | rs60336907 | chr8:89476919 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.11 | 4.7E-7 | Electrodermal activity |
| THCA | cis | rs12748152 | 1 | rs60340200 | chr1:27287716 | ZDHHC18 | chr1:27153201-27182207:+ | 0.73 | 7.54 | 2.42E-13 | HDL cholesterol;Triglycerides;LDL cholesterol |
| THCA | cis | rs932541 | 1 | rs6034489 | chr20:16456812 | KIF16B | chr20:16252749-16554078:- | -0.16 | -3.77 | 0.000186 | Intelligence |
| THCA | cis | rs932541 | 1 | rs6034490 | chr20:16457021 | KIF16B | chr20:16252749-16554078:- | -0.16 | -3.77 | 0.000186 | Intelligence |
| THCA | cis | rs2129782 | 1 | rs60350282 | chr8:89460917 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs6988636 | 1 | rs60362869 | chr8:124189971 | FAM83A | chr8:124191287-124222317:+ | -0.3 | -3.9 | 0.000108 | Urinary uromodulin levels |
| THCA | cis | rs7267979 | 1 | rs6037086 | chr20:25306338 | ENTPD6 | chr20:25176339-25207360:+ | 0.31 | 6.96 | 1.09E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6037086 | chr20:25306338 | FAM182A | chr20:26035250-26067552:+ | 0.18 | 3.41 | 0.000693 | Liver enzyme levels (alkaline phosphatase) |